Biosensors have proven to be indispensable measuring devices in numerous vital areas. For example, detecting the presence and concentration of specific molecules, so-called biomarkers, for early detection of diseases requires sensitive and reliable measurement methods. Moreover, rapid developments in the field of nanotechnology lead to nanomaterials with new properties and associated innovative applications. Thus, nanotechnology also has a far-reaching impact on biosensors' development: combining both fields leads to biosensors with greater sensitivity and shorter response times and results in precise and cost-effective sensor platforms. Nanobiosensors hold high potential for integration and miniaturization and can operate directly at the point of care- serving as a bridge between diagnostics and routine tests.
This talk focuses on applying nanostructured biosensors for the sensitive and label-free detection of analytes in real-time. A distinct aim is the continuous monitoring of biomarkers with compact read-out systems to provide direct, valuable feedback in real-time. First, an adequate functionalization of nanostructured sensor surfaces with suitable DNA-based receptors is required to enable subsequent detection of the analytes in solution. Based on this, universal strategies for confining nanobiosensor platforms are presented using different sensor systems, analytes, and characterization methods.
Stephanie has studied chemical engineering at the TU Dresden from 2006 to 2013. In October 2012 she joined Dr. L. Baraban's group for her diploma thesis: "Surface modification of SiNW based sensors with stimuli responsive polymer brushes". From October 2013 to 2015, Stephanie continued her work at our chair within the project "BioPlasNano", where she focused on functionalization and implementation of vertically aligned gold nanostructures for LSPR sensor applications. Since 2016, she is part of the iEGSEMP Korea Graduate School and works on the label-free detection of (stress) hormones with nanowire based sensor devices.
Biosensors have proven to be indispensable measuring devices in numerous vital areas. For example, detecting the presence and concentration of specific molecules, so-called biomarkers, for early detection of diseases requires sensitive and reliable measurement methods. Moreover, rapid developments in the field of nanotechnology lead to nanomaterials with new properties and associated innovative applications. Thus, nanotechnology also has a far-reaching impact on biosensors' development: combining both fields leads to biosensors with greater sensitivity and shorter response times and results in precise and cost-effective sensor platforms. Nanobiosensors hold high potential for integration and miniaturization and can operate directly at the point of care- serving as a bridge between diagnostics and routine tests.
This talk focuses on applying nanostructured biosensors for the sensitive and label-free detection of analytes in real-time. A distinct aim is the continuous monitoring of biomarkers with compact read-out systems to provide direct, valuable feedback in real-time. First, an adequate functionalization of nanostructured sensor surfaces with suitable DNA-based receptors is required to enable subsequent detection of the analytes in solution. Based on this, universal strategies for confining nanobiosensor platforms are presented using different sensor systems, analytes, and characterization methods.
Stephanie has studied chemical engineering at the TU Dresden from 2006 to 2013. In October 2012 she joined Dr. L. Baraban's group for her diploma thesis: "Surface modification of SiNW based sensors with stimuli responsive polymer brushes". From October 2013 to 2015, Stephanie continued her work at our chair within the project "BioPlasNano", where she focused on functionalization and implementation of vertically aligned gold nanostructures for LSPR sensor applications. Since 2016, she is part of the iEGSEMP Korea Graduate School and works on the label-free detection of (stress) hormones with nanowire based sensor devices.
