| Funding period: | Aug. 1, 2024 to July 31, 2027 |
| Agency: | DFG |
| Funding scheme: | Normalverfahren (Sachbeihilfe) |
We acknowledge funding by the DFG Normalverfahren (Sachbeihilfe) project "Subµ- to nano-scaled strategies to control initial bacterial colonization in the oral cavity and ex vivo – efficacies and modes of action" (Project number 533771434; grant agreement ID: CU 44/67-1).
Bacterial surface attachment and colonization can have negative effects in clinical environment, e. g. in the oral cavity, leading to health and financial issues. For example, biofilm formation on non-shedding surfaces is still a key challenge in dental research; bacterial spreading by adhesion on medical materials ex vivo can result in infections and severe biofilm formation in vivo, which is still a severe problem in hospital and medical environment.
Depending on the specific surface area of application, different strategies must be developed to counteract this phenomenon. Conditions can vary in presence of biomolecules, ionic strength and bacterial strains, including different metabolic states. This project aims at in-depth analysis of the underlying mode of action of biphasic textures in the oral cavity, but also intends to dissect other protocols by basic research on charge amplified surface structures for non-oral applications.
In this project we intend to follow two routes to understand the docking pathways of bacteria to surface:
Route (A), which is about research on plain chemical patterns, called biphasic nano-textures,
Route (B), which is about the exploration of combinations of charge and structural effects in the submicron- and nano-scale.
This aims to promote the preparation of a roadmap on effectiveness and limits of chemical textures and structured substrates regarding the suppression of bacterial colonization and carry over under different environmental conditions.
| Funding period: | Aug. 1, 2024 to July 31, 2027 |
| Agency: | DFG |
| Funding scheme: | Normalverfahren (Sachbeihilfe) |
We acknowledge funding by the DFG Normalverfahren (Sachbeihilfe) project "Subµ- to nano-scaled strategies to control initial bacterial colonization in the oral cavity and ex vivo – efficacies and modes of action" (Project number 533771434; grant agreement ID: CU 44/67-1).
Bacterial surface attachment and colonization can have negative effects in clinical environment, e. g. in the oral cavity, leading to health and financial issues. For example, biofilm formation on non-shedding surfaces is still a key challenge in dental research; bacterial spreading by adhesion on medical materials ex vivo can result in infections and severe biofilm formation in vivo, which is still a severe problem in hospital and medical environment.
Depending on the specific surface area of application, different strategies must be developed to counteract this phenomenon. Conditions can vary in presence of biomolecules, ionic strength and bacterial strains, including different metabolic states. This project aims at in-depth analysis of the underlying mode of action of biphasic textures in the oral cavity, but also intends to dissect other protocols by basic research on charge amplified surface structures for non-oral applications.
In this project we intend to follow two routes to understand the docking pathways of bacteria to surface:
Route (A), which is about research on plain chemical patterns, called biphasic nano-textures,
Route (B), which is about the exploration of combinations of charge and structural effects in the submicron- and nano-scale.
This aims to promote the preparation of a roadmap on effectiveness and limits of chemical textures and structured substrates regarding the suppression of bacterial colonization and carry over under different environmental conditions.
