Here we demonstrate a first combination of droplets microfluidics with the compact silicon nanowire field effect transistor (SiNW FET) in the microfluidic channel for in flow electrical detection of aqueous reactor-drops. Apart from detection events, we chemically probe the content of numerous droplets in a row as independent events (up to 104), and resolve the pH values and ionic strength of the solution, resulted in a change of a source-drain current ISD through the nanowires. We demonstrate the capability of the novel droplets based nanowire platform for bioassay applications and carry out a glucose oxidase (GOx) enzymatic test for glucose detection. Optic-less and noninvasive measurements of these parameters in aqueous droplets have a great impact on the area of biodetection and bioanalytics as a HTS tool for pathogens, drug assays, and evaluation of the enzymatic activities.
Here we demonstrate a first combination of droplets microfluidics with the compact silicon nanowire field effect transistor (SiNW FET) in the microfluidic channel for in flow electrical detection of aqueous reactor-drops. Apart from detection events, we chemically probe the content of numerous droplets in a row as independent events (up to 104), and resolve the pH values and ionic strength of the solution, resulted in a change of a source-drain current ISD through the nanowires. We demonstrate the capability of the novel droplets based nanowire platform for bioassay applications and carry out a glucose oxidase (GOx) enzymatic test for glucose detection. Optic-less and noninvasive measurements of these parameters in aqueous droplets have a great impact on the area of biodetection and bioanalytics as a HTS tool for pathogens, drug assays, and evaluation of the enzymatic activities.
